The FDA approved BOTOX® for therapeutic use in 1989. Adults with mild to severe frown wrinkles were authorized for BOTOX® in 2002. It was the first and only FDA-approved treatment for improving moderate to severe frown lines, crow’s feet, and forehead wrinkles in adults.
Many things contribute to facial wrinkles. It’s not simply about cellular changes, collagen loss, or free radical damage from the sun and environment.
Frequently frowning, squinting, or lifting the brows causes skin to furrow and fold, resulting in facial lines. It temporarily lowers the underlying muscle activity that creates moderate to severe frown lines, crow’s feet, and forehead lines in adults, making them appear smoother.
More than 16 years of study and 528 papers in peer-reviewed scientific and medical journals have demonstrated the safety and effectiveness of BOTOX® Cosmetic. BOTOX® Cosmetic is now the most extensively researched cosmetic therapy.